ABSTRACT Chrysin (CHR), a naturally occurring flavone recognized for its anti‐inflammatory and antioxidant activities, exhibits medicinal properties; nevertheless, the clinical use is constrained by inadequate absorption and limited bioavailability. This research employed poly‐lactic‐co‐glycolic acid (PLGA) as a nanodrug carrier to enhance the bioavailability, solubility, and effectiveness of CHR in protecting mice against lipopolysaccharide (LPS)‐acute liver and kidney damage. CHR‐loaded PLGA nanoparticles (CHR‐NPs) were synthesized and analyzed. Mice were allocated into six groups ( n = 8/group): control, LPS, Dexa (5 mg/kg), PLGA (50 mg/kg), CHR (50 mg/kg), and CHR‐NP (50 mg/kg). CHR‐NP improved liver and kidney function, alleviated histopathological abnormalities, and elevated enzymatic and non‐enzymatic antioxidants while reducing iron deposition, lipid peroxidation, and proinflammatory mediators. Furthermore, the Keap1/Nrf2/HO‐1 signaling pathway was upregulated after oral administration of CHR‐NP. Through activating the Keap1/Nrf2/HO‐1 signaling pathways, our data demonstrate that CHR‐NP significantly alleviated acute liver and kidney injury by inhibiting oxidative stress and inflammation.
Abdelmawgood et al. (Sun,) studied this question.