Key result
Chrysin effectively ameliorated methionine and choline-deficient diet-induced fatty liver in NAFLD mice by targeting the hepatic oxidative stress/PKC/HNF4α signaling pathway.
Why the study?
Does chrysin ameliorate hepatic steatosis in a mouse model of NAFLD?
Does chrysin ameliorate hepatic steatosis in a mouse model of NAFLD?
Chrysin ameliorates diet-induced fatty liver in mice by modulating the oxidative stress/PKC/HNF4α signaling pathway to increase VLDL secretion.
Chrysin may mitigate experimental NAFLD via PKC; hypothesis-generating in mice and requires human trials before any clinical consideration.
We investigated the effects of chrysin (CHR) on nonalcoholic fatty liver disease (NAFLD) in mice. The NAFLD mouse model was established using a diet deficient in methionine and choline (MCD). CHR was shown to attenuate MCD-induced hepatic fat accumulation, increase very low-density lipoprotein (VLDL) secretion, and decrease hepatic oxidative stress in NAFLD mice. Inhibition of oxidative stress or direct suppression of protein kinase C (PKC) by CHR significantly reduced PKC activity in the liver, leading to a decrease in inhibitory phosphorylation of hepatocyte nuclear factor 4α (HNF4α). The resulting activation of HNF4α led to induced transcription of apolipoprotein B and VLDL secretion. Together, these results show that CHR effectively ameliorates MCD-induced fatty liver in NAFLD mice by targeting the hepatic oxidative stress/PKC/HNF4α signaling pathway.
No takes yet. Share an insight, caveat, or question.
Song et al. (2020) studied Nonalcoholic fatty liver disease (NAFLD). Chrysin (CHR) vs. MCD diet alone was evaluated on Hepatic fat accumulation, VLDL secretion, and hepatic oxidative stress. Chrysin effectively ameliorated methionine and choline-deficient diet-induced fatty liver in NAFLD mice by targeting the hepatic oxidative stress/PKC/HNF4α signaling pathway.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: