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February 19, 2026Clinical and Experimental MedicineOpen Access

The role of tumor-associated macrophages in cancer development and their significance as prognostic markers

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Authors

ASArash SalmaninejadSLSepideh Mehrpour LayeghiZFZeinab Falakian

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Overview

Review explores tumor-associated macrophages' influence on cancer progression and their potential as biomarkers.

Key Points

  • The aim is to review the origin, polarization, and prognostic significance of tumor-associated macrophages in cancer.
  • Reviewed literature on tumor-associated macrophages and their roles.
  • Examined the polarization of macrophages and its impact on tumor progression.
  • Discussed the correlation of macrophage accumulation with cancer prognosis.
  • Highlighted tumor-associated macrophages' dual role in both suppressing and promoting tumors.
  • Noted the correlation between high levels of tumor-associated macrophages and poor patient prognosis.
  • Indicated the potential for targeting macrophage polarization as a therapeutic approach.

Cite This Study

Salmaninejad et al. (2026) studied this question.

synapsesocial.com/papers/6996a7a5ecb39a600b3ed7f0https://doi.org/10.1007/s10238-026-02055-0
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