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July 29, 2026Journal of Cancer Research and Clinical OncologyOpen Access

The pivotal role of macrophages in tumorigenesis and pioneering cancer immunotherapy across pre-clinical and clinical frontiers

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Authors

MAMina AlimohammadiAMAmir Mohammad MirnejadNFNajma Farahani

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Overview

Review investigates the role of tumor-associated macrophages in cancer progression and therapy strategies, highlighting their potential as crucial therapeutic targets.

Key Points

  • This review explores the function of tumor-associated macrophages (TAMs) in cancer progression and therapy.
  • Analysis of TAM origins, polarization, and metabolism
  • Investigation of therapeutic strategies targeting TAMs in preclinical and clinical settings
  • Examination of TAMs as drug delivery systems and predictors of patient outcomes
  • TAMs promote cancer proliferation, metastasis, and angiogenesis in multiple cancer types.
  • Therapeutic strategies targeting TAMs include suppressing recruitment, depleting TAMs, and re-educating them.
  • Combining single-cell profiling with multi-target therapies shows promise for enhancing TAM-based cancer treatments.

Cite This Study

Alimohammadi et al. (2026) studied this question.

synapsesocial.com/papers/6a69a2e2c8da07d9defa6e47https://doi.org/10.1007/s00432-026-06566-x
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