What question did this study set out to answer?

The goal is to combine Cinnamomum burmani essential oil with Cymbopogon spp. oils to enhance antibacterial activity against S. mutans while reducing cytotoxicity.

February 19, 2026Flavour and Fragrance JournalOpen Access

Formulation Strategy of Cymbopogon spp. Essential Oils to Reduce Irritation of Cinnamomum Burmani Essential Oil While Preserving Anti‐ Streptococcus mutans Activity

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YZYing‐Yu ZhangBeijing Technology and Business University SPSu‐Yeon ParkBeijing Technology and Business University YYYue YuanBeijing Technology and Business University

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Demonstrates reduced irritation while preserving antibacterial effects in oral biofilm management, suggesting safer alternatives.

Key Points

The goal is to combine Cinnamomum burmani essential oil with Cymbopogon spp. oils to enhance antibacterial activity against S. mutans while reducing cytotoxicity.
Characterization of essential oil compositions using GC-MS
Screening of optimal oil combinations via agar diffusion method
Determination of MIC/MBC using microbroth dilution method
Evaluation of antibacterial effects through time-kill assays and biofilm staining
Assessment of cytotoxicity using MTT assay on RAW 264.7 cells
Synergistic effects were observed in combinations CNEO:CBEO (2:3), CCEO:CBEO (1:1), and CKEO:CBEO (1:4)
Biofilm formation was inhibited by 73.25%-91.25% at sub-inhibitory concentrations
Key virulence gene expression was downregulated, impacting biofilm and acid tolerance
Cymbopogon combinations showed significantly reduced cytotoxicity in RAW 264.7 cells compared to CBEO alone

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6996a7b5ecb39a600b3edb2f https://doi.org/10.1002/ffj.70067

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Formulation Strategy of Cymbopogon spp. Essential Oils to Reduce Irritation of Cinnamomum Burmani Essential Oil While Preserving Anti‐ Streptococcus mutans Activity

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Cite This Study

Formulation Strategy of Cymbopogon spp. Essential Oils to Reduce Irritation of Cinnamomum Burmani Essential Oil While Preserving Anti‐ Streptococcus mutans Activity

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