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February 19, 2026Journal of PerinatologyOpen Access

A non-invasive diagnostic tool for the assessment of optimal positive-end expiratory pressure (PEEPOPT) in infants receiving prolonged invasive ventilation

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Authors

NDNada DarwishPenn State Milton S. Hershey Medical CenterADAnn M. DonnellyPennsylvania State UniversityJEJ. ErkingerPenn State Milton S. Hershey Medical Center

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Implication

Retrospective review assesses PEEP optimization in infants on mechanical ventilation, indicating feasibility and impact on lung function.

Key Points

  • The aim is to evaluate the feasibility of optimizing positive end-expiratory pressure (PEEP) using ventilator software in infants requiring mechanical ventilation.
  • Retrospective review of infants undergoing PEEP optimization studies.
  • Used paired-t test to compare dynamic lung compliance, tidal volume, and oxygen saturation before and after intervention.
  • Included infants with bronchopulmonary dysplasia and those receiving prolonged mechanical ventilation.
  • PEEP OPT was different from clinically set PEEP in 14 out of 15 infants.
  • PEEP OPT was higher in 27% and lower in 67% of infants.
  • Dynamic lung compliance increased by an average of 0.23 mL/H2O (p < 0.001).
  • Tidal volume increased by 1.5 mL/kg (p < 0.001).
  • Oxygen saturation increased by an average of 2% (p < 0.001).

Cite This Study

Darwish et al. (2026) studied this question.

synapsesocial.com/papers/6996a7c3ecb39a600b3edcechttps://doi.org/10.1038/s41372-026-02579-z
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