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February 19, 2026ACS Applied Materials & Interfaces

Coordination Self-Assembly of a Carrier-Free Hyaluronic Acid-Modified Nanoplatform for Augmented Photothermal/Chemodynamic Therapy and Robust Antimetastatic Immunity

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Authors

YPYanzheng PanFirst Affiliated Hospital of Henan UniversityHTHanxiao TangChina Academy of Chinese Medical SciencesXMXiaochang MaChinese Academy of Medical Sciences & Peking Union Medical College

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Implication

Innovative nanoplatform improves drug delivery and boosts anti-tumor immunity in cancer treatment, suggesting potent therapeutic advancements.

Key Points

  • This research aims to develop a carrier-free nanoplatform that enhances the efficacy of PTT and CDT while addressing limitations posed by the tumor microenvironment.
  • Developed a carrier-free nanoplatform via coordination self-assembly of luteolin and Fe3+ modified with hyaluronic acid.
  • Evaluated drug loading efficiency and encapsulation capacity.
  • Assessed dual responsiveness to glutathione and near-infrared lasers for controlled drug release.
  • Investigated the interaction of Lut with HSP90 and HIF-1α to enhance therapeutic effects.
  • Analyzed the induction of immunogenic cell death and systemic antitumor immunity.
  • Achieved 90.46% encapsulation efficiency and 85.86% drug loading efficiency, surpassing conventional systems.
  • Enabled simultaneous PTT and Fe3+-mediated CDT under near-infrared irradiation.
  • Induced immunogenic cell death, activating systemic antitumor immunity and effectively suppressing metastasis.

Cite This Study

Pan et al. (2026) studied this question.

synapsesocial.com/papers/6996a7c3ecb39a600b3edcfchttps://doi.org/10.1021/acsami.5c24185
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