What does this research mean for the field?

LINC00900 is a potential diagnostic biomarker for papillary thyroid carcinoma with lymph node metastasis and promotes tumor progression by interacting with miR-545-3p. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To explore the regulatory mechanism between LINC00900 and miR-545-3p in papillary thyroid carcinoma with lymph node metastasis.

February 19, 2026Turkish Journal of BiochemistryOpen Access

Diagnostic value of lncRNA LINC00900 in papillary thyroid carcinoma metastasis and its oncogenic role through sponging miR-545-3p

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Authors

YCYinglei CuiHangzhou Hospital of Traditional Chinese Medicine NANuerbol AslibekGaochun People's Hospital YYYing YangNanjing University of Science and Technology

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Implication

Investigates the role of LINC00900 in lymph node metastasis of papillary thyroid carcinoma, suggesting diagnostic implications.

Key Points

To explore the regulatory mechanism between LINC00900 and miR-545-3p in papillary thyroid carcinoma with lymph node metastasis.
Analyzed expression levels of LINC00900 and miR-545-3p via qPCR in 218 patients.
Utilized correlation tests, chi-square test, and ROC curve analysis to assess clinical associations.
Performed dual-luciferase assays to confirm binding sites between LINC00900 and miR-545-3p.
Conducted functional tests (CCK-8, transwell) to evaluate tumor cell behavior such as proliferation and invasion.
Elevated LINC00900 expression correlates with aggressive tumor features like larger size and advanced TNM stage.
High levels of LINC00900 are present in patients with thyroid carcinoma and lymph node metastasis compared to benign cases.
A negative correlation was found between LINC00900 and miR-545-3p in tumor tissues.
LINC00900 knockdown upregulates miR-545-3p and significantly inhibits tumor cell proliferation, migration, and invasion.

Cite This Study

Cui et al. (2026) studied this question.

synapsesocial.com/papers/6996a7ffecb39a600b3ee409 https://doi.org/10.1515/tjb-2025-0375

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Diagnostic value of lncRNA LINC00900 in papillary thyroid carcinoma metastasis and its oncogenic role through sponging miR-545-3p

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Implication

Key Points

Cite This Study

Diagnostic value of lncRNA LINC00900 in papillary thyroid carcinoma metastasis and its oncogenic role through sponging miR-545-3p

Discussion

Member takes

Implication

Key Points

Cite This Study

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