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(E)-Methyl 3-(2-amino-4-chloro-6-morpholinopyrimidin-5-yl)acrylate | Synapse

February 19, 2026Molbank0 citationsOpen Access

(E)-Methyl 3-(2-amino-4-chloro-6-morpholinopyrimidin-5-yl)acrylate

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JTJorge TrillerasUniversity of Atlántico EPEfraín Polo-CuadradoUniversity of Concepción JQJairo Quiroga

Key Points

To synthesize (E)-methyl 3-(2-amino-4-chloro-6-morpholinopyrimidin-5-yl)acrylate using a specific reaction.
Utilized a Schlosser-modified Wittig reaction for synthesis.
Performed 1H and 13C NMR for structure confirmation.
Confirmed E-alkene formation through complete signal assignments.
Successfully synthesized target compound (E)-methyl 3-(2-amino-4-chloro-6-morpholinopyrimidin-5-yl)acrylate.
Achieved complete NMR signal assignments confirming structural integrity.

Abstract

The synthesis of methyl (E)-3-(2-amino-4-chloro-6-morpholinopyrimidin-5-yl)acrylate 3 was accomplished using a Schlosser-modified Wittig reaction. Complete 1H and 13C NMR signal assignments confirm the formation of E-alkene.

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Cite This Study

Trilleras et al. (Mon,) studied this question.

synapsesocial.com/papers/6996a80aecb39a600b3ee5e0 https://doi.org/https://doi.org/10.3390/m2141