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This experiment shows how varying intraocular pressure affects light scatter in rabbit corneas, suggesting implications for eye health.
The intraocular pressures of 18 enucleated rabbit eyes were varied with a manometer system, and biomicroscopic photographs of the corneal sections taken at 45°. The negatives obtained were analyzed for optical density with a recording microdensitometer. Changes in negative density were related to percentage changes in light scatter by the corneas. These scatter changes, due to the variation of intraocular pressures, were analyzed and are discussed in terms of the hypothesis of Maurice, and its relationship to applied pressure and edema. Increasing or decreasing the applied pressure beyond the “normal” for the rabbit gave an increased amount of light scatter.
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Norman E. Wallis (1969) studied this question.
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