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February 19, 2026International Journal of Molecular SciencesOpen Access

Metabolic Regulation in the Maintenance of Drosophila Testis Stem Cells

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Authors

JLJiao LiuShanghai Jiao Tong UniversityPXPeixin XuUniversity of MacauYLYing LiuShenyang Pharmaceutical University

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Implication

This review uncovers metabolic influences on stem cell homeostasis in Drosophila, indicating broader implications for mammalian biology.

Key Points

  • This review aims to summarize the role of metabolic regulation in maintaining testis stem cells in Drosophila.
  • Analysis of metabolic profiles of germline stem cells and somatic cyst stem cells
  • Examination of signaling pathways such as insulin/TOR, BMP, and JAK-STAT
  • Assessment of mitochondrial dynamics and lipid metabolism impacts
  • Distinct metabolic profiles identified in germline and somatic stem cells
  • Germline stem cells maintain identity through TOR signaling regulation
  • Dysregulated metabolism can lead to stem cell depletion and reproductive decline

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/6996a818ecb39a600b3ee7c8https://doi.org/10.3390/ijms27041884
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