What question did this study set out to answer?

The aim is to review clinical practice guidelines and consensus statements for diagnosing and managing SJS/TEN in pediatric patients.

February 19, 2026Pediatric DermatologyOpen Access

Diagnosis and Management of Stevens‐Johnson Syndrome and Toxic Epidermal Necrolysis in Pediatric Patients: A Systematic Review of Clinical Guidelines and Consensus Statements

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A systematic review evaluates clinical guidelines for diagnosing and managing SJS/TEN in children, highlighting the need for standardized care.

The aim is to review clinical practice guidelines and consensus statements for diagnosing and managing SJS/TEN in pediatric patients.
Systematic search of multiple databases for national and international guidelines on pediatric SJS/TEN
Focused on documents providing recommendations for patients under 18 years
Quality assessment using AGREE II instrument
Ten guidelines met inclusion criteria, with 60% published in the last 5 years
90% endorsed supportive measures like wound care and fluid resuscitation
Pharmacologic therapy recommendations varied widely, lacking clear pediatric dosing guidance
Only one guideline mentioned biologics and long-term follow-up was covered by 50%

Creighton et al. (2026) studied this question.

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A systematic review evaluates clinical guidelines for diagnosing and managing SJS/TEN in children, highlighting the need for standardized care.