Mukhadushika (Acne vulgaris) is a common dermatological disorder predominantly affecting adolescents and young adults, leading to cosmetic disfigurement and psychological distress. Ayurveda describes Mukhadushika under Kshudra Roga, with various external formulations (Lepa Kalpana) recommended for its management. Mukhasaundaryakar Yavadi Lepa, mentioned in classical texts, is indicated for enhancing facial complexion and treating acne-related lesions and discoloration. However, conventional lepa formulations pose challenges such as limited shelf life, difficulty in preparation, and reduced patient compliance. The present study aimed to carry out a pharmaceutico-analytical evaluation of Mukhasaundaryakar Yavadi Lepa and to develop a novel, patient-friendly dosage form by converting it into a cream, while preserving classical Ayurvedic principles. Pharmaceutical preparation, physicochemical analysis, and standardization of both lepa and cream were performed. The developed cream exhibited acceptable organoleptic properties, physicochemical parameters, and stability, indicating its suitability as an alternative topical formulation. The study concludes that modification of Mukhasaundaryakar Yavadi Lepa into cream improves convenience and acceptability without compromising therapeutic potential.
2Dr. Jyoti Gavali *1Dr. Ankita Agrawal (Mon,) studied this question.