What question did this study set out to answer?

To evaluate the effectiveness of a TeleHealth exercise intervention in improving dose intensity during chemotherapy in older women with breast cancer.

February 19, 2026Clinical Cancer Research

Abstract PS5-09-01: The TeleHealth Resistance Exercise Intervention to Preserve Dose Intensity and Vitality in Elder Breast Cancer Patients (THRIVE-65) Trial

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To evaluate the effectiveness of a TeleHealth exercise intervention in improving dose intensity during chemotherapy in older women with breast cancer.
Phase II randomized controlled trial
Multicomponent exercise intervention with protein support versus health education control
Eligibility: women age ≥65 with stage I-III breast cancer undergoing chemotherapy
Measurements include physical function, quality of life, and body composition
Analysis plans for treatment effects based on RDI achievement
115 women randomized across 3 medical centers
Hypothesizes 82-89% of intervention group will achieve RDI of 85%
Notable focus on enhancing physical function and reducing treatment-related toxicity

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Implication

The THRIVE-65 trial evaluates exercise and nutrition support to improve dose intensity in elderly breast cancer patients, suggesting a meaningful impact on treatment outcomes.

Cite This Study

Schleicher et al. (2026) studied this question.

synapsesocial.com/papers/6996a82decb39a600b3eeab3 https://doi.org/10.1158/1557-3265.sabcs25-ps5-09-01

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Implication

The THRIVE-65 trial evaluates exercise and nutrition support to improve dose intensity in elderly breast cancer patients, suggesting a meaningful impact on treatment outcomes.

Abstract PS5-09-01: The TeleHealth Resistance Exercise Intervention to Preserve Dose Intensity and Vitality in Elder Breast Cancer Patients (THRIVE-65) Trial

Key Points

Discussion

Implication

Cite This Study

Abstract PS5-09-01: The TeleHealth Resistance Exercise Intervention to Preserve Dose Intensity and Vitality in Elder Breast Cancer Patients (THRIVE-65) Trial

Key Points

Discussion

Implication

Cite This Study

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