Simultaneous Brain Iron and α-Synuclein Detection in Patients with Synucleinopathies via Quantitative Susceptibility Mapping MRI

Key Points

• The aim is to differentiate between synucleinopathies and healthy controls using MRI imaging techniques.
• Performed subvoxel quantitative susceptibility mapping MRI.
• Simultaneously imaged alpha-synuclein aggregation and iron deposition.
• Compared imaging results between participants with synucleinopathies and healthy controls.
• Successfully detected the diamagnetic signal of alpha-synuclein.
• Differentiated participants with synucleinopathies from healthy controls based on imaging results.