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February 19, 2026CosmeticsOpen Access

Palmitoleic (16:1 n−7) Acid and Skin Health: Functional Roles and Opportunities for Topical and Oral Product Applications

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Authors

MOManuel OliveiraXZXiaoying ZhouMCMona CorreaCheck Point (Israel)

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Overview

Mini-review uncovers antimicrobial effects and benefits of palmitoleic acid for skin health, suggesting innovative product applications.

Key Points

  • This review aims to explore the roles of palmitoleic acid in skin health and its potential for topical and oral applications.
  • Reviewed skin lipid composition and functional roles of palmitoleic acid (POA)
  • Summarized experimental and preclinical evidence regarding POA's effects on skin
  • Reviewed early clinical findings on oral POA supplementation trials
  • Palmitoleic acid shows promising antimicrobial effects and enhances lubrication properties
  • Protects skin from oxidative and UVB injury, promoting improved wound repair
  • Oral supplementation trials indicate enhanced skin hydration and barrier function

Cite This Study

Oliveira et al. (2026) studied this question.

synapsesocial.com/papers/6996a85cecb39a600b3eeffbhttps://doi.org/10.3390/cosmetics13010045
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Trans-Palmitoleic Acid, Metabolic Risk Factors, and New-Onset Diabetes in U.S. Adults2010 · 348 citations
  2. 2Assessing Fatty Acid Profiles of Macadamia Nuts2019 · 21 citations
  3. 3Lubricant and Bactericidal Properties of Calcium Salts of Fatty Acids: Effect of Degree of Unsaturation2015 · 17 citations
  4. 4A review of fatty acids influencing skin condition2020 · 86 citations
  5. 5Metabolism of essential fatty acids by human epidermal enzyme preparations: evidence of chain elongation.1990 · 127 citations