What does this research mean for the field?

Lithium treatment is associated with a decrease in kidney function, as indicated by lower estimated Glomerular filtration rate (eGFR) compared to non-lithium controls in patients with affective disorders. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

What question did this study set out to answer?

This review investigates the impact of lithium on kidney function in individuals with affective disorders compared to non-lithium treatments.

February 19, 2026Therapeutic Advances in PsychopharmacologyOpen Access

Lithium nephrotoxicity: a systematic review and meta-analysis of lithium versus non-lithium control studies in patients with affective disorders

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Authors

MMMarie Michele MacaronUniversity of Miami MRMireilla Abou RjeilyUCLouvain RMRaphael MacaronMcGill University

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Implication

Systematic review assesses kidney function in patients on lithium versus non-lithium treatments, indicating significant effects on eGFR.

Key Points

This review investigates the impact of lithium on kidney function in individuals with affective disorders compared to non-lithium treatments.
Conducted a systematic review and meta-analysis.
Searched multiple databases including Cochrane and PubMed up to October 2023.
Screened observational studies comparing kidney function outcomes in lithium and non-lithium groups.
Assessed risk of bias using the ROBINS-E tool.
The lithium group showed a mean eGFR decline of −11.14 ml/min/1.73 m² compared to non-lithium.
Annual eGFR decline favored the non-lithium group with a mean difference of 0.13 ml/min/1.73 m².
Serum creatinine levels were higher in the lithium group by 0.05 mg/dl.
No statistically significant difference was found in chronic kidney disease incidence between groups.

Cite This Study

Macaron et al. (2026) studied this question.

synapsesocial.com/papers/6996a879ecb39a600b3ef2b7 https://doi.org/10.1177/20451253261419633

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Lithium nephrotoxicity: a systematic review and meta-analysis of lithium versus non-lithium control studies in patients with affective disorders

Discussion

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Implication

Key Points

Cite This Study

Lithium nephrotoxicity: a systematic review and meta-analysis of lithium versus non-lithium control studies in patients with affective disorders

Discussion

Member takes

Implication

Key Points

Cite This Study

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