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February 19, 2026Clinical Cancer Research

Abstract PS3-12-07: Tertiary Lymphoid Structures as Histopathologic Biomarkers in Invasive Breast Cancer: Subtype-Specific Patterns and Clinical Implications

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Authors

ACA. J. CozzoSAS. C. Van AlstenLOL. T. Olsson

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Overview

This analysis evaluates TLS as biomarkers in invasive breast cancer, revealing subtype-specific patterns and implications for treatment response.

Key Points

  • Investigate the role of tertiary lymphoid structures (TLS) as biomarkers in invasive breast cancer and their association with clinical outcomes.
  • Evaluated histopathologic and immune features associated with TLS using histology-based scoring and gene modeling.
  • Used H&E-stained whole slide images from the Carolina Breast Cancer Study for scoring TLS and tumor-infiltrating lymphocytes (TILs).
  • Assessed associations with survival outcomes using multinomial logistic and Cox models.
  • Developed gene expression classifiers for TLS and TIL groups and validated them in the I-SPY2 trial dataset.
  • TLS identified in 38% of tumors, with significant variations in presence and maturity.
  • Patients with mature TLS (mTLS) were over twice as likely to show intratumoral presence compared to those with immature TLS (iTLS).
  • mTLS presence significantly correlated with improved progression-free survival (PFS) in ER-negative tumors.
  • Predicted mTLS was linked to the highest pathologic complete response (pCR) rates in the overall cohort and specific subgroups.

Cite This Study

Cozzo et al. (2026) studied this question.

synapsesocial.com/papers/6996a879ecb39a600b3ef422https://doi.org/10.1158/1557-3265.sabcs25-ps3-12-07
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