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December 1, 2025Apmis

Prognostic Value of Tertiary Lymphoid Structures in Primary Breast Cancer and Their Association With Immune Microenvironment

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Authors

YXYunxia XuSLShubei LiuXLXiaokai Ling

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Overview

Observational analysis highlights tertiary lymphoid structures' role as biomarkers for prognosis evaluation in breast cancer, suggesting improved outcomes with higher estrogen receptor levels.

Key Points

  • Improved prognosis is associated with the presence of tertiary lymphoid structures in breast cancer.
  • Analysis showed significant correlation with estrogen receptor and prognosis evaluation based on immunohistochemical staining.
  • Kaplan–Meier survival analysis indicated a favorable trend for recurrence-free survival among TLS-positive tumors.
  • Presence of TLS correlates with increased CD4 + T cell infiltration, implicating immune microenvironment importance.

Cite This Study

Xu et al. (2025) studied this question.

synapsesocial.com/papers/69402a7e2d562116f2902200https://doi.org/10.1111/apm.70114
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