What question did this study set out to answer?

This research investigates the antitumor effects of a novel postbiotic product derived from sequential fermentation of L.paracasei NPB01 and L.rhamnosus GG against breast cancer.

February 19, 2026Clinical Cancer Research

Abstract PS2-12-02: An Innovative Postbiotic Product Based on Sequential Fermentation of L.paracasei NPB01 and L.rhamnosus GG Demonstrates Antitumor Activity against Breast Cancer

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Authors

RCR. Berni CananiFederico II University Hospital CLC. LuongoFederico II University Hospital LPLaura PisapiaInstitute of Genetics and Biophysics

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Implication

Innovative postbiotic product reduces tumor cell viability and migration in breast cancer, suggesting potential therapeutic benefits.

Key Points

This research investigates the antitumor effects of a novel postbiotic product derived from sequential fermentation of L.paracasei NPB01 and L.rhamnosus GG against breast cancer.
Assessed cell viability in breast cancer subtypes using colony formation assays.
Evaluated apoptosis rates with Annexin V and 7-AAD staining.
Measured HLA class I expression using flow cytometry.
Investigated cell migration effects through wound healing assays.
Over 50% reduction in colony formation in MCF7, MDA-MB-231, and SKBR3 cells after exposure to iPB at 0.5 mg/ml for 72 h.
Increased early and late apoptosis rates in MCF7 and triple-negative breast cancer cells exposed to iPB.
30% increase in HLA class I expression in all breast cancer cell types following iPB treatment.
iPB treatment led to a 30% reduction in cell migration in breast cancer models, compared to untreated controls.

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Canani et al. (2026) studied this question.

synapsesocial.com/papers/6996a879ecb39a600b3ef447 https://doi.org/10.1158/1557-3265.sabcs25-ps2-12-02

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Abstract PS2-12-02: An Innovative Postbiotic Product Based on Sequential Fermentation of L.paracasei NPB01 and L.rhamnosus GG Demonstrates Antitumor Activity against Breast Cancer

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Cite This Study

Abstract PS2-12-02: An Innovative Postbiotic Product Based on Sequential Fermentation of L.paracasei NPB01 and L.rhamnosus GG Demonstrates Antitumor Activity against Breast Cancer

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Key Points

Cite This Study

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