What question did this study set out to answer?

To determine the impact of tumor response during first-line therapy on long-term clinical outcomes in patients with HR+/HER2- advanced breast cancer.

February 19, 2026Clinical Cancer Research

Abstract PS1-10-29: Complete tumor response during first-line endocrine therapy (ET) plus Cyclin Dependent Kinase 4/6 inhibitors (CDK4/6i) predicts excellent clinical outcomes in patients with Hormone Receptor-positive, Human Epidermal growth factor Receptor 2-negative advanced Breast Cancer (HR+/HER2- aBC)

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To determine the impact of tumor response during first-line therapy on long-term clinical outcomes in patients with HR+/HER2- advanced breast cancer.
Conducted the PALMARES-2 study across 25 Italian institutions
Analyzed tumor responses (CR, PR, SD, PD) and their impact on progression-free survival and overall survival
Implemented multivariable Cox regression to adjust for confounding factors
12.4% of patients achieved complete response (CR), with significantly better progression-free survival than those achieving partial response (PR), stable disease (SD), or progressive disease (PD)
High tumor expression of estrogen receptor alpha and certain metastasis characteristics increased CR likelihood
Factors such as older age and endocrine resistance reduced the probability of achieving CR

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Implication

This real-world study shows that complete tumor response predicts superior clinical outcomes in HR+/HER2- advanced breast cancer, indicating potential treatment adjustments.

Cite This Study

Vernieri et al. (2026) studied this question.

synapsesocial.com/papers/6996a887ecb39a600b3ef52b https://doi.org/10.1158/1557-3265.sabcs25-ps1-10-29

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Implication

This real-world study shows that complete tumor response predicts superior clinical outcomes in HR+/HER2- advanced breast cancer, indicating potential treatment adjustments.

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Discussion

Implication

Cite This Study

Key Points

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Implication

Cite This Study

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