What question did this study set out to answer?

This analysis aims to understand how palbociclib's effectiveness varies according to the SETER/PR index and previous chemotherapy regimens in HR+/HER2- breast cancer.

February 19, 2026Clinical Cancer Research

Abstract PS3-08-13: Exploratory analysis of palbociclib benefit in the PALLAS trial by SETERPR index and prior chemotherapy regimens (ABCSG-42/AFT-05/BIG-14-13)

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This analysis aims to understand how palbociclib's effectiveness varies according to the SETER/PR index and previous chemotherapy regimens in HR+/HER2- breast cancer.
Evaluated invasive disease-free survival using Kaplan-Meier plots.
Compared treatment groups with a log-rank test.
Utilized Cox models to estimate hazard ratios and 95% confidence intervals.
Analyzed the SETER/PR index in a cohort of 3,090 PALLAS patients.
Palbociclib patients with prior anthracycline-paclitaxel chemotherapy showed longer invasive disease-free survival.
In patients with intermediate SETER/PR index (0.75 to <1.50), palbociclib significantly improved outcomes (HR 0.58, p=0.004).
The hazard ratio suggested palbociclib is beneficial for patients with SETER/PR values between 1.1 and 1.8.

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Implication

Exploratory analysis reveals varying palbociclib benefits in breast cancer based on endocrine sensitivity and prior therapy.

Cite This Study

Metzger et al. (2026) studied this question.

synapsesocial.com/papers/6996a898ecb39a600b3ef7b5 https://doi.org/10.1158/1557-3265.sabcs25-ps3-08-13

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Abstract PS3-08-13: Exploratory analysis of palbociclib benefit in the PALLAS trial by SETERPR index and prior chemotherapy regimens (ABCSG-42/AFT-05/BIG-14-13)

Key Points

Discussion

Implication

Cite This Study

Abstract PS3-08-13: Exploratory analysis of palbociclib benefit in the PALLAS trial by SETERPR index and prior chemotherapy regimens (ABCSG-42/AFT-05/BIG-14-13)

Key Points

Discussion

Implication

Cite This Study

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