What question did this study set out to answer?

The study aimed to analyze the genomic landscape of locally advanced triple negative breast cancer samples and correlate these findings with treatment response.

February 19, 2026Clinical Cancer Research

Abstract PS4-03-22: High throughput analysis in locally advanced triple negative breast cancer TNBC: pathological complete response pCR and mutational status

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The study aimed to analyze the genomic landscape of locally advanced triple negative breast cancer samples and correlate these findings with treatment response.
Retrospective analysis of 48 core biopsies from patients with triple negative breast cancer.
Assessment of pathological complete response after neoadjuvant chemotherapy.
Sequencing using the TruSight Oncology 500 panel to evaluate somatic mutations.
Statistical analysis performed with Chi-squared test and R Studio.
Statistically significant correlations between PIK3CA mutations and lack of pathological complete response.
Most frequently altered genes included TP53 (94%) and PIK3CA (21%).
PIK3CA alterations were present in 39% of non-responders but absent in responders.
Median tumor mutation burden in non-responders was 5.5 compared to 4.8 in responders.

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Implication

Demonstrated the impact of genomic mutations on treatment response in triple negative breast cancer, indicating potential predictive biomarkers.

Cite This Study

Paris et al. (2026) studied this question.

synapsesocial.com/papers/6996a898ecb39a600b3ef884 https://doi.org/10.1158/1557-3265.sabcs25-ps4-03-22

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Implication

Demonstrated the impact of genomic mutations on treatment response in triple negative breast cancer, indicating potential predictive biomarkers.

Abstract PS4-03-22: High throughput analysis in locally advanced triple negative breast cancer TNBC: pathological complete response pCR and mutational status

Key Points

Discussion

Implication

Cite This Study

Abstract PS4-03-22: High throughput analysis in locally advanced triple negative breast cancer TNBC: pathological complete response pCR and mutational status

Key Points

Discussion

Implication

Cite This Study

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