What question did this study set out to answer?

This study aims to explore the association between Oncotype DX Recurrence Score and germline mutations in breast cancer susceptibility genes.

February 19, 2026Clinical Cancer Research

Abstract PS3-08-24: Association of Oncotype DX Recurrence Score with Germline Mutations in Cancer Susceptibility Genes Including BRCA1/2 in HR+/HER2− Early Breast Cancer

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This study aims to explore the association between Oncotype DX Recurrence Score and germline mutations in breast cancer susceptibility genes.
Retrospective analysis of a Greek cohort of early-stage ER+/HER2- breast cancer patients
Patients underwent germline testing with a 52-gene panel and Oncotype DX testing
Oncotype DX RS categorized into low, intermediate, and high-risk genomic groups
Higher median Oncotype DX RS values observed in patients with BRCA1/2 and high-risk gene variants (p<0.0001)
Increased percentage of patients with RS>25 for those with high-risk variants (p<0.0001)
Notable distribution differences in RS across various genetic variant groups

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Implication

This analysis investigates the relationship between Oncotype DX RS and germline mutations in breast cancer, indicating significant implications for prognosis.

Cite This Study

Venizelos et al. (2026) studied this question.

synapsesocial.com/papers/6996a8a9ecb39a600b3ef892 https://doi.org/10.1158/1557-3265.sabcs25-ps3-08-24

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Implication

This analysis investigates the relationship between Oncotype DX RS and germline mutations in breast cancer, indicating significant implications for prognosis.

Abstract PS3-08-24: Association of Oncotype DX Recurrence Score with Germline Mutations in Cancer Susceptibility Genes Including BRCA1/2 in HR+/HER2− Early Breast Cancer

Key Points

Discussion

Implication

Cite This Study

Abstract PS3-08-24: Association of Oncotype DX Recurrence Score with Germline Mutations in Cancer Susceptibility Genes Including BRCA1/2 in HR+/HER2− Early Breast Cancer

Key Points

Discussion

Implication

Cite This Study

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