What question did this study set out to answer?

Assess pathological complete response rates and treatment patterns, and evaluate survival outcomes in high-risk HER2-positive early breast cancer.

February 19, 2026Clinical Cancer Research

Abstract PS5-04-09: Pathological complete response rates, treatment patterns, and survival outcomes in high risk, neoadjuvant-treated HER2-positive early breast cancer: a Canadian chart review

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Authors

WCW. Y. CheungUniversity of Calgary JHJ-W. HenningUniversity of Calgary SSS. ShokarSeneca Polytechnic

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Implication

This retrospective chart review shows treatment patterns and survival outcomes in high-risk HER2-positive early breast cancer, indicating important implications for patient care.

Key Points

Assess pathological complete response rates and treatment patterns, and evaluate survival outcomes in high-risk HER2-positive early breast cancer.
Retrospective chart review of patients with high-risk HER2-positive early breast cancer treated with neoadjuvant therapy at Alberta cancer centers from 2013 to 2022.
Analysis of pathological complete response rates, surgical types, complications, and subsequent adjuvant therapy utilization.
Survival outcomes were analyzed using Kaplan-Meier methods and Cox regression for associations with clinical factors.
65.2% of patients were hormone receptor positive, with 46.9% achieving pathological complete response.
Patients with pathological complete response had higher 5-year recurrence-free survival (90.1% vs 80.8%) and overall survival rates (91.3% vs 87.3%).
Pathological complete response was associated with a reduced risk of adverse outcomes across all survival metrics (rwRFS, rwEFS, rwiDFS, rwOS) with significant hazard ratios.

Cite This Study

Cheung et al. (2026) studied this question.

synapsesocial.com/papers/6996a8a9ecb39a600b3efa68 https://doi.org/10.1158/1557-3265.sabcs25-ps5-04-09

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Implication

This retrospective chart review shows treatment patterns and survival outcomes in high-risk HER2-positive early breast cancer, indicating important implications for patient care.

Abstract PS5-04-09: Pathological complete response rates, treatment patterns, and survival outcomes in high risk, neoadjuvant-treated HER2-positive early breast cancer: a Canadian chart review

Discussion

Member takes

Implication

Key Points

Cite This Study

Abstract PS5-04-09: Pathological complete response rates, treatment patterns, and survival outcomes in high risk, neoadjuvant-treated HER2-positive early breast cancer: a Canadian chart review

Discussion

Member takes

Implication

Key Points

Cite This Study

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