What does this research mean for the field?

African American breast cancer patients have worse median overall survival compared to Non-Hispanic White patients, influenced by differences in the tumor immune microenvironment and biopsy site. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

What question did this study set out to answer?

To characterize differences in the tumor immune microenvironment in Hispanic and African American breast cancer patients by biopsy site.

February 19, 2026Clinical Cancer Research

Abstract PS3-12-06: Immune microenvironment and survival differences among Hispanic and African American breast cancer cases by biopsy site

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Authors

RHRobert HsuUniversity of Southern California SDS. Kumar DeshmukhCaris Life Sciences (United States)NGNana Gyabaah-KessieUniversity of Southern California

Discussion

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Implication

Examines tumor immune environment differences affecting survival among racial groups, suggesting important treatment considerations.

Key Points

To characterize differences in the tumor immune microenvironment in Hispanic and African American breast cancer patients by biopsy site.
Analyzed 19,459 breast cancer samples using NGS and WTS techniques.
Self-reported race/ethnicity data were used to group patients.
Immune cell proportions estimated via WTS deconvolution.
Gene expression evaluated for T-cell inflammed score and MAPK activation score.
Survival data analyzed using Kaplan-Meier methods.
African American patients showed lower M2 macrophage proportion in primary and lymph node biopsies.
Hispanic patients had better CD8+ T cell infiltration compared to African American patients in primary tumors.
African Americans had worse median overall survival in primary and lymph node biopsies compared to Non-Hispanic Whites.
Liver biopsies showed low T cell infiltration across all racial groups, with worse overall survival across the board.
In HER2+ primary biopsies, Hispanic patients displayed significantly worse overall survival compared to Non-Hispanic Whites.

Cite This Study

Hsu et al. (2026) studied this question.

synapsesocial.com/papers/6996a8b5ecb39a600b3efa8b https://doi.org/10.1158/1557-3265.sabcs25-ps3-12-06

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Abstract PS3-12-06: Immune microenvironment and survival differences among Hispanic and African American breast cancer cases by biopsy site

Discussion

Member takes

Implication

Key Points

Cite This Study

Abstract PS3-12-06: Immune microenvironment and survival differences among Hispanic and African American breast cancer cases by biopsy site

Discussion

Member takes

Implication

Key Points

Cite This Study

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