What question did this study set out to answer?

This research aims to evaluate the effectiveness and safety of hypofractionated whole breast irradiation with concomitant boost in early-stage breast cancer.

February 19, 2026Clinical Cancer Research

Abstract PS4-08-22: Hypofractionated Whole Breast Irradiation with Concomitant Boost following Breast Conservation Surgery in Early-Stage Breast Cancer

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This research aims to evaluate the effectiveness and safety of hypofractionated whole breast irradiation with concomitant boost in early-stage breast cancer.
Retrospective identification of patients treated with HFRT WBI with concomitant boost from 2013 to 2025.
Data collected included patient demographics, treatment details, adverse events, and cosmetic outcomes.
Radiation toxicities graded using CTCAE v4.0 and cosmetic outcomes assessed using the NRG-RTOG Global Cosmetic Score.
Included 407 patients with 343 invasive breast cancer and 64 ductal carcinoma in situ.
Excellent/good cosmetic outcomes in 96% at 1 year and 89% at 3 years; no poor outcomes reported.
Three-year ipsilateral breast recurrence rate was 0.98%, with 98.3% disease-free survival at three years.

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Implication

Retrospective analysis shows HFRT with concomitant boost achieves high local control in early-stage breast cancer, suggesting it as a beneficial treatment option.

Cite This Study

Kumar et al. (2026) studied this question.

synapsesocial.com/papers/6996a8b5ecb39a600b3efbc3 https://doi.org/10.1158/1557-3265.sabcs25-ps4-08-22

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Implication

Retrospective analysis shows HFRT with concomitant boost achieves high local control in early-stage breast cancer, suggesting it as a beneficial treatment option.

Abstract PS4-08-22: Hypofractionated Whole Breast Irradiation with Concomitant Boost following Breast Conservation Surgery in Early-Stage Breast Cancer

Key Points

Discussion

Implication

Cite This Study

Abstract PS4-08-22: Hypofractionated Whole Breast Irradiation with Concomitant Boost following Breast Conservation Surgery in Early-Stage Breast Cancer

Key Points

Discussion

Implication

Cite This Study

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