Why the study?
Cardiac damage staging systems may better characterize myocardial and extracardiac involvement, prompting evaluation of cardiac damage presence and progression across the clinical course of AS.
Does echocardiographic cardiac damage progress across clinically defined stages of aortic stenosis prior to TAVR?
Population
179 consecutive TAVR patients with serial echocardiograms across AS stages
Comparison
Moderate AS vs first severe AS vs pre-TAVR symptomatic severe AS
Design
Single-center retrospective cohort study
Follow-up
Median 32 months from moderate to severe AS
Key result
LV GLS worsened from -18.1% to -14.9% and RVAc declined from 1.0 to 0.7 as AS progressed to severe stages, independent of symptoms (p < 0.05).
Authors
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May support GLS/RVAc for early AS risk stratification; hypothesis-generating pending prospective validation.
Does echocardiographic cardiac damage progress across clinically defined stages of aortic stenosis prior to TAVR?
Echocardiographic markers of cardiac damage, such as LV GLS and RV-arterial coupling, worsen early in the progression of aortic stenosis before symptom onset, suggesting their utility in early risk stratification.
Rivadeneira-Ruiz et al. (2026) studied this question. LV GLS worsened from -18.1% to -14.9% and RVAc declined from 1.0 to 0.7 as AS progressed to severe stages, independent of symptoms (p < 0.05).
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