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June 3, 2021European Heart Journal - Quality of Care and Clinical OutcomesOpen Access

Refined staging classification of cardiac damage associated with aortic stenosis and outcomes after transcatheter aortic valve implantation

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Why the study?

A new staging classification of aortic stenosis characterizing the extent of cardiac damage was established and validated, but an updated classification system needed validation in patients undergoing TAVI.

Does a refined staging classification of cardiac damage predict 1-year mortality in patients with aortic stenosis undergoing TAVI?

Population

1156 AS patients undergoing TAVI

Comparison

Updated stages of cardiac damage (Stage 0 to Stage 4)

Design

Prospective registry study

Follow-up

1 year

Authors

TOTaishi OkunoDHDik HegJLJonas Lanz

Discussion

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Overview

Cardiac damage staging stratifies post-TAVI mortality risk; hypothesis-generating and requires prospective validation before guiding decisions.

Structured PICO

Does a refined staging classification of cardiac damage predict 1-year mortality in patients with aortic stenosis undergoing TAVI?

P
Population
1,156 patients with aortic stenosis undergoing transcatheter aortic valve implantation (TAVI)
I
Intervention
Refined staging classification of cardiac damage (Stages 0-4, including sub-stages 3a/b and 4a/b/c) assessed prior to TAVI
C
Comparator
Lower stages of cardiac damage (Stage 0-1)
O
Outcome
All-cause death at 1 yearhard clinical

Advanced cardiac damage (severe pulmonary hypertension or RV dysfunction) prior to TAVI is associated with a five- to seven-fold increased risk of 1-year mortality.

Cite This Study

Okuno et al. (2021) studied this question.

synapsesocial.com/papers/69aee159b53de84d00abdda0https://doi.org/10.1093/ehjqcco/qcab041
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