Abstract PS4-12-14: Clinicopathological Features of Gestational Breast Cancer in Syria: A Comparative Study

AbstractBackground: Syria faces a particularly high burden of breast cancer. Gestational breast cancer represents a distinct and complex subset of breast malignancies. It is defined as breast cancer diagnosed during pregnancy or within one year postpartum. It affects approximately one in every 3000 pregnancies. There is a notable gap in research comparing the demographic, clinical, and pathological characteristics of gestational breast cancer patients and other breast cancer patients within the Syrian context. This study aims to address this gap by providing a comprehensive comparison between these two distinct groups in Syria. Methods: This retrospective cohort study included patients with a histologically confirmed diagnosis of breast cancer between January 1, 2005, and June 1, 2025. Data were retrieved from Al-Bairouni University Hospital's breast registry. Results: Our study included 164 female patients diagnosed with Breast Cancer. Patients were distributed among two groups: “Gestational breast cancer” group and “Other breast cancer patients” group. The gestational group consisted of 80 patients, while the other group consisted of 84 patients. Invasive ductal carcinoma was the most common histological subtype among both groups (90.2%). Tumors in the right breast were seen more in gestational breast cancer patients (60%) compared to the other group (38.8%). HER2-positive status was higher in the gestational group (59.7%). PR positivity was also higher in gestational breast cancer patients (56.3%). Conclusion: Our findings suggest that patients with gestational breast cancer in Syria may present with more aggressive biological features, particularly regarding HER2 expression. This could affect treatment strategies and disease prognosis. However, the endpoints of our study are identifying disease free survival and overall survival in both groups, which hasn’t been reached yet. Keywords: breast cancer, human epidermal growth factor receptor 2, pregnancy, Syria Citation Format: M. Al ali, A. Kouli, A. Al-Bitar, M. Saifo. Clinicopathological Features of Gestational Breast Cancer in Syria: A Comparative Study [abstract]. In: Proceedings of the San Antonio Breast Cancer Symposium 2025; 2025 Dec 9-12; San Antonio, TX. Philadelphia (PA): AACR; Clin Cancer Res 2026;32(4 Suppl):Abstract nr PS4-12-14.