What does this research mean for the field?

Pathological complete response (pCR) rates following neoadjuvant chemotherapy in breast cancer patients treated in Bahia, Brazil, are 22%, with significant variations by tumor subtype and race. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

What question did this study set out to answer?

The aim is to evaluate pathological complete response rates and breast-conserving surgery outcomes in breast cancer patients undergoing neoadjuvant chemotherapy.

February 19, 2026Clinical Cancer Research

Abstract PS4-11-29: Pathological Complete Response and Breast-Conserving Surgery in Patients Undergoing Neoadjuvant Chemotherapy for Breast Cancer in an Institution fully Funded by the Brazilian Public Health System in Bahia, Brazil

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The aim is to evaluate pathological complete response rates and breast-conserving surgery outcomes in breast cancer patients undergoing neoadjuvant chemotherapy.
Included 286 women who underwent surgery post-neoadjuvant chemotherapy from Jan/2018 to Dec/2021.
Patients with multifocal/multicentric tumors and other specific criteria were excluded.
Tumors were classified by molecular subtype to assess treatment outcomes.
Surgical procedures categorized as conventional BCS, oncoplastic BCS, or mastectomy.
Overall pathological complete response was 22%, with higher rates in HER2/HR− (49%) and triple-negative subtypes (26%).
Surgery type: 64% mastectomy (19% with reconstruction), 36% breast-conserving surgery.
42% of non-inflammatory cases had conservative surgery, lower than international averages.
Access to consistent trastuzumab treatment was limited, with 63% of HER2+ cases receiving it.

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Implication

Case series evaluates pathological response rates in breast cancer patients, highlighting treatment disparities.

Cite This Study

Camarotti et al. (2026) studied this question.

synapsesocial.com/papers/6996a8d4ecb39a600b3efe80 https://doi.org/10.1158/1557-3265.sabcs25-ps4-11-29

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Abstract PS4-11-29: Pathological Complete Response and Breast-Conserving Surgery in Patients Undergoing Neoadjuvant Chemotherapy for Breast Cancer in an Institution fully Funded by the Brazilian Public Health System in Bahia, Brazil

Key Points

Discussion

Implication

Cite This Study

Abstract PS4-11-29: Pathological Complete Response and Breast-Conserving Surgery in Patients Undergoing Neoadjuvant Chemotherapy for Breast Cancer in an Institution fully Funded by the Brazilian Public Health System in Bahia, Brazil

Key Points

Discussion

Implication

Cite This Study

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