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February 19, 2026Clinical Cancer Research

Abstract PS1-01-18: Temperature-controlled hand-foot cooling prevents chemotherapy-induced polyneuropathy (cipn): a real-world data collection in 500 patients

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Authors

AKA. KostaraTSTina SchönbergerOOO. Opra

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Overview

Real-world data collection reveals temperature-controlled cooling prevents chemotherapy-induced neuropathy in breast cancer patients, indicating a beneficial supportive care strategy.

Key Points

  • This research aims to assess the effectiveness of temperature-controlled hand-foot cooling in preventing chemotherapy-induced peripheral neuropathy (CIPN) during cancer treatment.
  • Utilized temperature-controlled hand-foot cooling (Hilotherapy®) during chemotherapy sessions
  • Applied cooling for 30 minutes before, during, and after infusion
  • Evaluated CIPN symptoms using CTCAE v5.0 criteria
  • Stratified patients based on taxane dosing schedule
  • 90.4% of patients experienced mild or no CIPN symptoms (grade 0-1)
  • 9.4% developed CIPN grade 2, and 0.2% experienced grade 3
  • Effectiveness of Hilotherapy® in preventing ≥ grade 2 CIPN was noted in over 90% of participants

Cite This Study

Kostara et al. (2026) studied this question.

synapsesocial.com/papers/6996a8d4ecb39a600b3efeeahttps://doi.org/10.1158/1557-3265.sabcs25-ps1-01-18
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Temperature-controlled hand-foot cooling for prevention of chemotherapy-induced polyneuropathy (CIPN): Updated real-world data collection in 600 patients.2026
  2. 2Chemotherapy-induced neurotoxicity in the treatment of gynecological cancers: State of art and an innovative approach for prevention2021 · 17 citations
  3. 3Controlled cooling therapy for the prevention of chemotherapy-induced peripheral neuropathy: a service evaluation2026
  4. 4Abstract PO3-12-10: Cryotherapy to Prevent Taxane-Induced Sensory Neuropathy of the Hands and Feet2024
  5. 5Prevention of taxane chemotherapy-induced nail changes and peripheral neuropathy by application of extremity cooling: a prospective single-centre study with intrapatient comparison2024 · 4 citations