ABSTRACT Quantitative susceptibility mapping (QSM) is a post‐processing magnetic resonance imaging technique that quantifies the magnetic susceptibility of biological tissue and provides insights into factors such as iron deposition, hemorrhage, calcification, myelin content, and oxygen extraction fraction. A variety of analytical approaches have been developed to interpret QSM data from different perspectives, including region‐of‐interest‐based, depth‐wise, surface‐based, network‐based, and voxel‐wise methods. Among these, voxel‐wise analysis has gained increasing prominence due to its ability to perform a detailed examination of the entire brain without anatomically predefined regions. This approach is especially valuable for investigating neurological pathologies and aging‐related changes, including neurodegenerative and neuropsychiatric disorders. This article aims to comprehensively summarize voxel‐wise analysis in QSM by outlining key methodological considerations and clinical applications. Moreover, it offers practical data processing recommendations to advance the reproducibility and transparency of voxel‐wise QSM research.
Tang et al. (Sun,) studied this question.