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February 19, 2026Clinical Cancer Research

Abstract PS2-06-16: Two cohorts of young women (41y at diagnosis) with invasive breast cancer: Single center data on how demographics, tumor characteristics, therapies and 5-year survival differ when treated 2000-2005 and 2014-2019

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Authors

BGB. GootsALAnnouschka LaenenSHS. Han

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Overview

Retrospective analysis compares demographics and outcomes in young women with breast cancer, showing significant improvements over 19 years.

Key Points

  • To compare demographics, tumor characteristics, therapies, and 5-year survival rates among young women with invasive breast cancer diagnosed before age 41 across two time periods.
  • Retrospective comparison of two cohorts diagnosed between 2000-2005 and 2014-2019
  • Analysis included demographics, tumor characteristics, therapies, and survival outcomes
  • Continuous variables were analyzed using Mann-Whitney U test; categorical variables using Fisher’s exact test
  • Cohort 1 had 233 patients; cohort 2 had 237 patients, with no significant age difference at diagnosis
  • Cohort 2 showed significantly higher rates of screening detection and neoadjuvant therapy
  • 5-year disease-free and distant relapse-free survival significantly improved from cohort 1 to cohort 2

Cite This Study

Goots et al. (2026) studied this question.

synapsesocial.com/papers/6996a8e3ecb39a600b3f00d3https://doi.org/10.1158/1557-3265.sabcs25-ps2-06-16
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