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February 19, 2026Developmental Neurobiology

Maternal Age at Childbirth and Offspring Cognitive Function in Middle and Older Age: A Longitudinal Cohort Study

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Authors

KYKai YuXWX Y WangYSYuexian Shi

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Overview

Longitudinal study examines cognitive performance linked to maternal age at childbirth in older offspring, suggesting implications for cognitive health.

Key Points

  • This research investigates the impact of maternal age at childbirth on cognitive function of offspring in their middle and older years.
  • Analyzed data from 3549 offspring in the China Health and Retirement Longitudinal Study (CHARLS).
  • Categorized maternal age into four groups: <22, 22–28, 29–35, and >35 years.
  • Employed linear mixed-effects models to estimate differences and rates of change in cognitive scores.
  • Adjusted for demographic, socioeconomic, lifestyle, and health-related covariates.
  • Advanced maternal age (>35 years) correlated with lower baseline cognitive scores.
  • The baseline cognitive score difference decreased but remained significant after covariate adjustments.
  • No significant difference in cognitive decline rates was found across maternal age groups.

Cite This Study

Yu et al. (2026) studied this question.

synapsesocial.com/papers/6996a8efecb39a600b3f02eehttps://doi.org/10.1002/dneu.70017
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