Complete blood count-based inflammatory ratios in people with bipolar disorder: A systematic review and meta-analysis of neutrophil-to-lymphocyte, monocyte-to-lymphocyte, and platelet-to-lymphocyte ratios

This is a Meta-Analysis study (also classified as: Systematic Review).

February 18, 2026European PsychiatryOpen Access

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Key Points

The central research question focuses on evaluating inflammatory ratios in relation to bipolar disorder.
Conducted a systematic review and meta-analysis
Examined neutrophil-to-lymphocyte, monocyte-to-lymphocyte, and platelet-to-lymphocyte ratios
Included studies focusing on complete blood count in patients with bipolar disorder
Identified significant alterations in inflammatory ratios among individuals with bipolar disorder
Concluded that inflammation may contribute to bipolar disorder's pathophysiology

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Systematic review shows altered complete blood count ratios in bipolar disorder, indicating inflammation may play a role.

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Cavaleri et al. (2026) studied this question.

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