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Recent advances improve pharmacological activities and combinatorial methods in oligonucleotide therapy, indicating promise in clinical applications.
Progress In oligonucleotide therapeutics continues at a rapid pace. This update will focus on recent progress In several key areas: clinical and preclinical development of oligonucleotide drugs, demonstration of pharmacological activities In animals, medicinal chemistry of oligonucleotides, novel oligonucleotide structures and combinatorial methods.
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Crooke St (1993) studied this question.
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