Cost-effectiveness of the GAAD algorithm for hepatocellular carcinoma surveillance of patients with compensated cirrhosis: a model-based analysis using Italian real-world data

Camilla Porta; Monica Cevenini; Giovanni Cirotto; Maria Teresa Majorini; Osvaldo Ulises Garay; Vincenza Calvaruso; Tommaso FASANO; Lucia Napoli; Francesco Giuseppe Foschi; Pietro Lampertico

doi:10.1080/13696998.2026.2627833

February 17, 2026Journal of Medical EconomicsOpen Access

Cost-effectiveness of the GAAD algorithm for hepatocellular carcinoma surveillance of patients with compensated cirrhosis: a model-based analysis using Italian real-world data

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Key Points

This research evaluates the cost-effectiveness of the GAAD algorithm for surveillance of hepatocellular carcinoma in patients with compensated cirrhosis.
Conducted a model-based analysis using Italian real-world data
Compared GAAD alone and combined with ultrasound for surveillance
Assessed the cost-effectiveness based on disease detection rates
GAAD alone or with ultrasound is cost-effective for HCC surveillance
Improved early-stage disease detection with the GAAD algorithm
Further performance data for the combined strategy is needed to validate findings

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Implication

Model-based analysis demonstrates cost-effective HCC surveillance in compensated cirrhosis patients, indicating improved early detection.

Abstract

GAAD, alone or combined with US, is a cost-effective strategy for HCC surveillance in CC patients in Italy, improving the detection of early-stage disease. Better performance data for US+GAAD is needed to confirm results.

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Porta et al. (2026) studied this question.

synapsesocial.com/papers/6997f984ad1d9b11b34523d1 https://doi.org/10.1080/13696998.2026.2627833

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Cost-effectiveness of the GAAD algorithm for hepatocellular carcinoma surveillance of patients with compensated cirrhosis: a model-based analysis using Italian real-world data

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Cost-effectiveness of the GAAD algorithm for hepatocellular carcinoma surveillance of patients with compensated cirrhosis: a model-based analysis using Italian real-world data

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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