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This analysis reports clinical toxicity outcomes in polypharmacy scenarios involving daridorexant, suggesting the need for heightened vigilance.
While daridorexant appears safe when taken alone, clinicians should remain vigilant in polypharmacy scenarios involving central nervous system depressants. Further studies are needed to confirm sex-related differences and refine risk stratification in overdose management.
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Fabeck et al. (2026) studied this question.
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