What question did this study set out to answer?

The aim is to evaluate long-term trends in acute kidney injury-related mortality and quantify demographic disparities among U.S. adults.

February 20, 2026Medicine BulletinOpen Access

National Trends and Structural Inequities in Acute Kidney Injury Mortality: A Joinpoint Analysis of CDC WONDER Data, 1999–2023

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Long-term trends in acute kidney injury mortality show significant demographic disparities, suggesting urgent public health interventions are needed.

The aim is to evaluate long-term trends in acute kidney injury-related mortality and quantify demographic disparities among U.S. adults.
Analyzed mortality data from CDC WONDER database (1999-2023)
Calculated age-adjusted mortality rates per 100,000 population
Estimated annual percent change (APC) and average annual percent change (AAPC)
Conducted stratified analyses by sex, race/ethnicity, age, and geographic region.
Overall age-adjusted mortality rate increased significantly from 1999 to 2008 (APC: 5.30%)
Decreased from 2008 to 2019 (APC: -3.58%)
Sharp rise again from 2019 to 2023 (APC: 12.29%)
Significant disparities observed, especially among males, non-Hispanic Black individuals, and older adults.
Widening disparities noted during the COVID-19 pandemic.

Chen et al. (2026) studied this question.

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Long-term trends in acute kidney injury mortality show significant demographic disparities, suggesting urgent public health interventions are needed.