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February 20, 2026Prenatal Diagnosis

Translating Emerging Data for Fetal Treatment of Cystic Fibrosis

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Authors

MZMichael V. ZaretskyYBYair J. BlumenfeldSSSylvia S. Szentpetery

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Overview

This review demonstrates favorable fetal treatment outcomes of cystic fibrosis in carriers, suggesting potential for improved therapies.

Key Points

  • The central aim is to evaluate the effects of CFTR modulator therapy during pregnancy on fetal cystic fibrosis treatment outcomes.
  • Reviewed animal studies and human cases
  • Assessed maternal pulmonary function and obstetrical outcomes
  • Analyzed prenatal treatment timing and complications in fetal cases
  • Examined CFTRm transmission through placenta and breastmilk
  • Two-thirds of treated fetal cases showed resolution of meconium ileus
  • Maternal pulmonary function was preserved compared to nonpregnant individuals
  • Lower-than-expected sweat chloride levels were observed
  • Nonresolution of meconium ileus was linked to later treatment initiation or complications

Cite This Study

Zaretsky et al. (2026) studied this question.

synapsesocial.com/papers/6997fa12ad1d9b11b3452fc3https://doi.org/10.1002/pd.70098
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1In Utero CFTR Modulator Therapy in Fetuses With Cystic Fibrosis2026
  2. 2INTRAUTERINE TREATMENT IN TWO FETUSES AFFECTED BY CYSTIC FIBROSIS.TO WHOM AND SINCE WHEN?REPORT OF CASES.2025
  3. 3Antenatal CFTR Modulators to Treat a Healthy Pregnant Woman with a Fetus Affected by Cystic Fibrosis Complicated by Meconium Ileus and Intestinal Volvulus: From a Suspicion of the Disease to a Targeted Treatment in Utero: Case Report and Narrative Review2026
  4. 4Pregnancy in Patients With Cystic Fibrosis.2025
  5. 5Exposure to CFTR Modulators During Pregnancy in Cystic Fibrosis: Four Cases to Highlight Neonatal Diagnostic Challenges and Outcomes2026