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March 2, 2026NeoReviews

In Utero CFTR Modulator Therapy in Fetuses With Cystic Fibrosis

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Authors

AMAdam MetcalfJHJordana E. HoppeSMStacey L. Martiniano

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Overview

Review explores the impact of CFTR modulator therapy to treat meconium ileus in fetuses, highlighting ethical considerations.

Key Points

  • This review aims to evaluate the use of CFTR modulator therapy during pregnancy to treat fetal cystic fibrosis complications.
  • Review existing data on CFTR modulator therapy during pregnancy
  • Examine reported effects on pregnant individuals and their offspring
  • Discuss potential benefits and risks associated with therapy
  • CFTR modulator therapy may prevent meconium ileus in fetuses
  • Possible to maintain exocrine pancreatic function in infants with CF
  • Ethical implications and knowledge gaps require further investigation

Cite This Study

Metcalf et al. (2026) studied this question.

synapsesocial.com/papers/69a52dd3f1e85e5c73bf0ef5https://doi.org/10.1542/neo.27-3-103
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Antenatal CFTR Modulators to Treat a Healthy Pregnant Woman with a Fetus Affected by Cystic Fibrosis Complicated by Meconium Ileus and Intestinal Volvulus: From a Suspicion of the Disease to a Targeted Treatment in Utero: Case Report and Narrative Review2026
  2. 2Translating Emerging Data for Fetal Treatment of Cystic Fibrosis2026 · 4 citations
  3. 3Ethical Considerations With CFTR Modulator Use in Pregnancy2026
  4. 4Exposure to CFTR Modulators During Pregnancy in Cystic Fibrosis: Four Cases to Highlight Neonatal Diagnostic Challenges and Outcomes2026
  5. 5INTRAUTERINE TREATMENT IN TWO FETUSES AFFECTED BY CYSTIC FIBROSIS.TO WHOM AND SINCE WHEN?REPORT OF CASES.2025