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February 20, 2026Critical Care Medicine

Safety of Enteral Feeding in Patients on High-Flow Nasal Cannula

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Authors

MWMichael R. WestUniversity of Southern CaliforniaECE. J. ChenJRJack RodmanSouthern California Clinical and Translational Science Institute

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Implication

A retrospective cohort study assesses aspiration risk and respiratory failure progression in adults on HFNC, suggesting enteral nutrition is safer.

Key Points

  • This study aims to evaluate the impact of enteral feeding on aspiration risk and respiratory failure progression among adults receiving high-flow nasal cannula oxygen therapy.
  • Conducted a single-center retrospective cohort study at Keck Hospital.
  • Included hospitalized adults treated with high-flow nasal cannula (HFNC) between January 2020 and December 2022.
  • Analyzed progression of respiratory failure among patients who were enterally fed versus those who were NPO.
  • Used multivariate mixed effects linear regression and propensity score matching for analysis.
  • Out of 220 patients, 57 showed progression of respiratory failure.
  • Enterally fed patients had a significantly lower risk of progression compared to those who were NPO (OR 0.33).
  • Propensity score-matched analysis further confirmed lower risk in enterally fed patients (OR 0.30).
  • No increased risk of poor clinical outcomes associated with enteral feeding was observed.

Cite This Study

West et al. (2026) studied this question.

synapsesocial.com/papers/6997fa26ad1d9b11b34532efhttps://doi.org/10.1097/ccm.0000000000007074
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Feeding during High‐Flow Nasal Cannula for Bronchiolitis: Associations with Time to Discharge2019 · 30 citations
  2. 2Oral Nutrition in Children With Bronchiolitis on High-Flow Nasal Cannula Is Well Tolerated2017 · 51 citations
  3. 3Enteral Nutrition Is a Risk Factor for Airway Complications in Subjects Undergoing Noninvasive Ventilation for Acute Respiratory Failure2016 · 69 citations
  4. 4High-flow nasal cannula oxygen therapy is superior to conventional oxygen therapy but not to noninvasive mechanical ventilation on intubation rate: a systematic review and meta-analysis2017 · 174 citations