In Medio Stat Virtus: Asymmetric Salphen Metal Complexes with Improved Biological Properties

Luisa D'Anna; Aurane Froux; Riccardo Bonsignore; Alexander Roller; Christian R. Kowol; Antonio Andrea Monari; Stéphanie Grandemange; Giampaolo Barone; Alessio Terenzi

doi:10.1039/d5dt02881g

January 1, 2026Dalton Transactions

In Medio Stat Virtus: Asymmetric Salphen Metal Complexes with Improved Biological Properties

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Key Points

This research aims to explore the biological properties of Zn(II) Salphen complexes, focusing on their potential anticancer effects.
Synthesis of three distinct Zn(II) Salphen complexes with varying ligand modifications.
Characterization of synthesized complexes to assess their chemical properties.
Evaluation of DNA binding affinity, cellular uptake, and anticancer activity through in vitro assays.
The synthesized Zn(II) Salphen complexes demonstrated significant DNA binding abilities.
Increased cellular uptake was observed, indicating improved delivery of the complexes to target cells.
At least one of the complexes exhibited notable anticancer activity in tested cancer cell lines.

Implication

Synthesis and analysis of salphen complexes show improved anticancer activity through enhanced DNA binding.

Abstract

We have synthesized and characterized three Zn(II) Salphen complexes with different ligand modifications to evaluate their biological properties in terms of DNA binding, cellular uptake and anticancer activity. Particular attention...

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Cite This Study

D'Anna et al. (2026) studied this question.

synapsesocial.com/papers/6997fa5aad1d9b11b345383e https://doi.org/10.1039/d5dt02881g

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In Medio Stat Virtus: Asymmetric Salphen Metal Complexes with Improved Biological Properties

Key Points

Implication

Abstract

Discussion

Cite This Study

In Medio Stat Virtus: Asymmetric Salphen Metal Complexes with Improved Biological Properties

Key Points

Implication

Abstract

Discussion

Cite This Study

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