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July 31, 2025

Dual Anticancer and Antimicrobial Activity of Novel Salicylal Carbothioamide Metal Complexes: Synthesis, Spectroscopic Characterization, and Molecular Docking Insights

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Authors

SASajid AliHTHeba S. TaherAIAhmed Z. Ibrahim

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Overview

Synthesis of metal complexes showed cytotoxicity against MCF-7 cells and antimicrobial activity in vitro, indicating novel therapeutic potential.

Key Points

  • Complexes AR4 and AK3 exhibited significant cytotoxicity against MCF-7 breast cancer cells with IC₅₀ values of 55.26 µM and 62.17 µM.
  • Antimicrobial tests showed moderate to good inhibition against both Gram-positive and Gram-negative bacterial strains.
  • Metal complexes were characterized using various techniques including spectroscopic analysis and thermal analysis.
  • Molecular docking studies revealed favorable binding energies with the cancer-associated protein TRPM7, supporting the compounds' potential activity.

Cite This Study

Ali et al. (2025) studied this question.

synapsesocial.com/papers/689a0c5fe6551bb0af8cf808https://doi.org/10.21203/rs.3.rs-7168690/v1
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