Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
April 10, 2026Chemistry & Biodiversity

Exploring the Anticancer and Antimicrobial Activities of Transition Metal Chelates Derived From Hydrazones: Synthesis, Spectral Investigation, Molecular Docking, and ADMET Profiling

View Full Paper
Ask AI
Bookmark
Share

Authors

MRManju RaniJDJai DeviBKBinesh Asok Kumar

Discussion

Loading...

Member takes

Overview

Exploring hydrazone complexes shows promising anticancer and antimicrobial activity in cancer cells and microbes, suggesting therapeutic use.

Key Points

  • This research aims to synthesize and evaluate the anticancer and antimicrobial properties of transition metal chelates derived from hydrazones.
  • Synthesis of hydrazone ligands from thiophene derivatives and diphenyl pyrazole aldehyde.
  • Formation of Co(II), Ni(II), Cu(II), and Zn(II) complexes.
  • Evaluation of complexes against cancer cell lines (A549, DU145) and microbial strains.
  • Molecular docking analysis to assess binding affinity with target proteins.
  • ADMET profiling to check pharmacokinetics and drug-likeness.
  • The Cu(II) complex showed the highest anticancer efficacy against A549 and DU145 cell lines while sparing IMR-90 cells.
  • Cu(II) and Zn(II) complexes displayed significant antimicrobial effects with MIC values between 0.0052-0.0104 µmol/mL, comparable to standard drugs.
  • Molecular docking results revealed strong binding scores, indicating strong interactions with target proteins.

Cite This Study

Rani et al. (2026) studied this question.

synapsesocial.com/papers/69d895d86c1944d70ce06ed7https://doi.org/10.1002/cbdv.202502755
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Unlocking the biological potential of transition metal complexes with Thiosemicarbazone ligands: Insights from computational studies2024 · 22 citations
  2. 2Design and Study of Novel Ni(II), Co(II), and Cu(II) Complexes With Hydrazone Ligand: Structural Characterization, DFT Analysis, and Assessment of Cytotoxic and Antioxidant Activities Supported by Molecular Docking Studies2025 · 8 citations
  3. 3Triazole-Based Schiff Base Metal Complexes: Synthesis, Characterization, Computational Studies and Biomedical Activity Against Cancer, H. pylori, and COVID-192024 · 3 citations
  4. 4Synthesis, calf thymus DNA binding, in-vitro cytotoxicity, molecular docking, and antimicrobial studies of novel metal complexes containing a 2,3-diaminopyridine derivative Schiff base2026
  5. 5Bioactive Transition Metal(II) Hydrazone Complexes: Spectral Elucidation, Antimalarial, Antioxidant, and Antimicrobial Activities Correlated With Molecular Docking and Absorption, Distribution, Metabolism, Excretion, and Toxicity2026 · 3 citations