ECG-GPT achieved expert-level ECG interpretation with diagnostic accuracy of 93%-99% and AUROCs 0.80-0.96 across 26 labels in 4.1 million ECGs.
Does ECG-GPT accurately generate expert-level interpretations from 12-lead ECG images compared to expert diagnosis?
ECG-GPT is a highly accurate, format-independent vision encoder-decoder model capable of generating expert-level interpretations directly from 12-lead ECG images.
Absolute Event Rate: 0% vs 0%
Abstract Background and Aims Timely, accurate assessment of electrocardiograms (ECGs) is crucial for diagnosing, triaging, and managing patients. However, this often relies on expert interpretation, a major bottleneck in low-resource settings. We developed and validated ECG-GPT, a format-independent vision encoder-decoder model that generates expert-level interpretations from 12-lead ECG images. Methods We developed ECG-GPT using 12-lead ECGs and their corresponding diagnosis statements performed at a large US health system between 2000 and 2022. Using structured clinical assessment, semantic similarity, and conventional metrics, we validated ECG-GPT across 7 distinct health settings, including 3 large and diverse US health systems, ECGs from Minas Gerais, Brazil, the UK Biobank, the Germany-based PTB-XL dataset, and a community hospital in Missouri. Results 2.9 million ECGs were used for model development, and 4.1 million ECGs for validation. The model performed well in clinical assessment across 26 extracted labels, with diagnostic accuracy ranging from 0.93-0.99. For rhythm abnormalities, including atrial fibrillation, sinus tachycardia, sinus bradycardia, premature atrial contractions, and premature ventricular contractions, AUROCs ranged from 0.80-0.95. For conduction abnormalities, including left bundle branch block, right bundle branch block, first degree atrioventricular block, left anterior fascicular block, and left posterior fascicular block, AUROCs ranged from 0.88-0.96. ECG-GPT identified the full context of diagnosis statements with allied conditions with a median pairwise similarity of 0.90, significantly greater than baseline (p0.001). Results were comparable across external validation sites. Conclusions We developed and validated a vision encoder-decoder model that generates expert-level interpretations from ECG images, a scalable strategy for accessible automated ECG analysis.
Khunte et al. (Wed,) reported a other. ECG-GPT achieved expert-level ECG interpretation with diagnostic accuracy of 93%-99% and AUROCs 0.80-0.96 across 26 labels in 4.1 million ECGs.