Exposure of red blood cell concentrates to temperatures below 0°C for a short period does not alter in vitro quality.

Natascha Roser; Mohamed Benbrika; Mauro Borri; Agathe Martin; David Crettaz; Jeremy Touati; Simon Hänni; Stefano Fontana; M. Prudent

doi:10.2450/bloodtransfus.1161

February 9, 2026

Exposure of red blood cell concentrates to temperatures below 0°C for a short period does not alter in vitro quality.

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Key Points

This research aims to assess the effect of short-term exposure of red blood cell concentrates to temperatures below freezing on their quality.
Analyzed two real cases of red blood cell concentrate exposure to sub-zero temperatures
Evaluated in vitro quality of red blood cells over the storage period
No damage to red blood cells was observed after cold exposure
Red blood cell concentrates showed resilience to storage temperature deviations

Implication

Case studies reveal no damage to red blood cells during short cold exposure, suggesting resilience.

Abstract

The two present real cases of RCCs exposure to temperatures below 0°C did not show damage to RBCs over storage. Even though the present work did not investigate the limits of RBCs sensitivity to cold temperature, it provides indications on the capability of RCCs to resist such type of storage deviation.

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Cite This Study

Roser et al. (2026) studied this question.

synapsesocial.com/papers/6997fa6dad1d9b11b3453ad0 https://doi.org/10.2450/bloodtransfus.1161

View at Publisher

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Exposure of red blood cell concentrates to temperatures below 0°C for a short period does not alter in vitro quality.

Key Points

Implication

Abstract

Discussion

Cite This Study

Exposure of red blood cell concentrates to temperatures below 0°C for a short period does not alter in vitro quality.

Key Points

Implication

Abstract

Discussion

Cite This Study

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