Key result
Higher hepatic steatosis linked to greater cardiovascular risk in NAFLD.
Why the study?
Hepatic steatosis is linked to metabolic disorders and atherosclerosis, but the association between cardiovascular risk and the degree of hepatic steatosis needed determination.
Cross-Sectional (n=250)
Non-random quota sampling
No
Effect estimate: Chi-square X² = 12.82
p-value: p=0.046
The degree of hepatic steatosis on ultrasound is directly associated with cardiovascular risk as measured by coronary calcium score, highlighting its utility in subclinical atherosclerosis risk stratification.
May support ultrasound steatosis grading for CV risk stratification in NAFLD; hypothesis-generating and requires prospective validation.
Background: Hepatic steatosis, currently recognized as a metabolic liver disease, is linked to the global epidemic of obesity, insulin resistance, type 2 diabetes, metabolic syndrome, and cardiovascular disorders. Cardiovascular disease is the leading cause of death worldwide. From a pathophysiological perspective, the accumulation of intrahepatic lipids is associated with chronic low-grade inflammation, oxidative stress, endothelial dysfunction, and activation for the development of atherosclerosis. These alterations result in an increased risk of ischemic heart disease and cardiovascular disease. Imaging plays a role in the non-invasive detection of hepatic steatosis in its different stages using abdominal ultrasound and in the evaluation of cardiovascular risk markers using cardiac computed tomography, as well as in the identification of atherosclerotic calcifications of the coronary arteries. General objective: To determine the association between cardiovascular risk and the degree of hepatic steatosis in patients treated at HGRO No 1. Material and methods: This is a cross-sectional, observational, prospective, and analytical study. Non-random quota sampling was used. Frequencies and percentages were obtained for qualitative variables, and measures of central tendency and dispersion were obtained for quantitative variables. The chi- square test was used for inferential statistics , achieving statistical significance with a p-value <0.05. The sample consisted of 250 patients with hepatic steatosis of varying degrees, who underwent cardiac tomography between May 2025 and July 2025 at HGRO 01. Results: This study included 250 patients, of whom 139 (56.6%) were women. The mean age was 50.02 years. Obesity was the predominant BMI in 89 patients (35.6%). Hypertension and diabetes mellitus were found in 87 patients (34.8%) and 85 patients (34%), respectively. Mild hepatic steatosis was the most prevalent, found in 98 patients (39.3%) , and very low cardiovascular risk was the most common, found in 96 patients (38.4%), with a statistically significant association ( X² = 12.82, p = 0.046). Conclusions: Cardiovascular risk is directly associated with the degree of hepatic steatosis, as a higher degree of hepatic steatosis was associated with a greater cardiovascular risk. Therefore, the alternative hypothesis can be confirmed, and the null hypothesis rejected . A high frequency of overweight and obesity was found. Furthermore, it can be concluded that diabetes mellitus and hypertension are important factors in this pathology.
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A et al. (2026) conducted a cross-sectional in Patients with non-alcoholic fatty liver disease diagnosed by ultrasound treated at a secondary care hospital (n=250). Assessment of cardiovascular risk using simple cardiac tomography with Agaston coronary calcium score was evaluated on Association between degree of hepatic steatosis by ultrasound and cardiovascular risk stratified by Agaston coronary calcium score from cardiac tomography (Chi-square X² = 12.82, p=0.046). The degree of hepatic steatosis was significantly associated with cardiovascular risk, with higher steatosis linked to higher risk (X²=12.82, p=0.046) in 250 NAFLD patients.
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