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October 3, 2008The American Journal of GastroenterologyOpen Access

Hepatic Steatosis and Subclinical Cardiovascular Disease in a Cohort Enriched for Type 2 Diabetes: The Diabetes Heart Study

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Key result

Hepatic steatosis correlated with visceral fat (r=-0.22, P<0.0001) and inflammatory biomarkers, but had no significant association with coronary, aortic, or carotid calcium.

Why the study?

Is hepatic steatosis associated with subclinical atherosclerosis and inflammatory biomarkers in a cohort enriched for type 2 diabetes?

Population

623 participants from the Diabetes Heart Study, a family study of sibling pairs concordant for type 2…

Design

Cross-sectional

Authors

RMRyan L. McKimmieThe Ohio State UniversityKDKurt R. DanielAtrium Health Wake Forest BaptistJCJ. Jeffrey CarrAmerican College of Radiology

Discussion

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Implication

Hepatic steatosis should not yet inform subclinical atherosclerosis risk stratification in T2D; leaves open its role as epiphenomenon of visceral inflammation.

Study Design

Type

Cross-Sectional (n=623)

Structured PICO

Is hepatic steatosis associated with subclinical atherosclerosis and inflammatory biomarkers in a cohort enriched for type 2 diabetes?

P
Population
623 participants from the Diabetes Heart Study, a family study of sibling pairs concordant for type 2 diabetes.
I
Intervention
Hepatic steatosis (defined as liver:spleen attenuation ratio <1.0 by computed tomography)
O
Outcome
Cross-sectional relationships between hepatic steatosis, regional fat accumulation (visceral and subcutaneous fat), inflammatory biomarkers (HDL, triglycerides, CRP, adiponectin), and subclinical measures of atherosclerosis (coronary, aortic, and carotid artery calcium; carotid intimal thickness)surrogate

Hepatic steatosis is associated with pro-atherogenic biomarkers and visceral fat but not directly with subclinical atherosclerosis, suggesting it is an epiphenomenon of a systemic pro-atherogenic state rather than a direct mediator of cardiovascular disease.

Cite This Study

McKimmie et al. (2008) conducted a cross-sectional in Type 2 diabetes (n=623). Hepatic steatosis was evaluated on Associations between liver:spleen attenuation ratio and regional fat accumulation, inflammatory biomarkers, and subclinical measures of atherosclerosis. Hepatic steatosis correlated with visceral fat (r=-0.22, P<0.0001) and inflammatory biomarkers, but had no significant association with coronary, aortic, or carotid calcium.

synapsesocial.com/papers/6a1788025fdf2a7b88aa1efbhttps://doi.org/10.1111/j.1572-0241.2008.02188.x

Topics

Women and heart disease
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Familial Aggregation of Coronary Artery Calcium in Families With Type 2 Diabetes2001 · 158 citations
  2. 2Race-Specific Relationships Between Coronary and Carotid Artery Calcification and Carotid Intimal Medial Thickness2004 · 48 citations
  3. 3Non‐alcoholic hepatic steatosis and its relation to increased plasma biomarkers of inflammation and endothelial dysfunction in non‐diabetic men. Role of visceral adipose tissue2005 · 178 citations